Endothelial SOCS3 maintains homeostasis and promotes survival in endotoxemic mice

SOCS3 is the main inhibitor of the JAK/STAT3 pathway. This pathway is activated by interleukin 6 (IL-6), a major mediator of the cytokine storm during shock. To determine its role in the vascular response to shock, we challenged mice lacking SOCS3 in the adult endothelium (SOCS3(iEKO)) with a nonlet...

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Detalles Bibliográficos
Autores principales: Martino, Nina, Ramos, Ramon Bossardi, Lu, Shuhan, Leyden, Kara, Tomaszek, Lindsay, Sadhu, Sudeshna, Fredman, Gabrielle, Jaitovich, Ariel, Vincent, Peter A., Adam, Alejandro P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410050/
https://www.ncbi.nlm.nih.gov/pubmed/34138760
http://dx.doi.org/10.1172/jci.insight.147280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410050/
https://www.ncbi.nlm.nih.gov/pubmed/34138760
http://dx.doi.org/10.1172/jci.insight.147280

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