Natural killer cells and cytotoxic T lymphocytes are required to clear solid tumor in a patient-derived xenograft

Existing patient-derived xenograft (PDX) mouse models of solid tumors lack a fully tumor donor–matched, syngeneic, and functional immune system. We developed a model that overcomes these limitations by engrafting lymphopenic recipient mice with a fresh, undisrupted piece of solid tumor, whereby tumo...

Descripción completa

Detalles Bibliográficos
Autores principales: Le, Duy Tri, Huynh, Tridu R., Burt, Bryan, Van Buren, George, Abeynaike, Shawn A., Zalfa, Cristina, Nikzad, Rana, Kheradmand, Farrah, Tyner, John J., Paust, Silke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Resource and Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410059/
https://www.ncbi.nlm.nih.gov/pubmed/34081628
http://dx.doi.org/10.1172/jci.insight.140116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410059/
https://www.ncbi.nlm.nih.gov/pubmed/34081628
http://dx.doi.org/10.1172/jci.insight.140116

Ejemplares similares