Cargando…
Natural killer cells and cytotoxic T lymphocytes are required to clear solid tumor in a patient-derived xenograft
Existing patient-derived xenograft (PDX) mouse models of solid tumors lack a fully tumor donor–matched, syngeneic, and functional immune system. We developed a model that overcomes these limitations by engrafting lymphopenic recipient mice with a fresh, undisrupted piece of solid tumor, whereby tumo...
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Clinical Investigation
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410059/ https://www.ncbi.nlm.nih.gov/pubmed/34081628 http://dx.doi.org/10.1172/jci.insight.140116 |