Key molecular alterations in endothelial cells in human glioblastoma uncovered through single-cell RNA sequencing

Passage of systemically delivered pharmacological agents into the brain is largely blocked by the blood-brain-barrier (BBB), an organotypic specialization of brain endothelial cells (ECs). Tumor vessels in glioblastoma (GBM), the most common malignant brain tumor in humans, are abnormally permeable,...

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Detalles Bibliográficos
Autores principales: Xie, Yuan, He, Liqun, Lugano, Roberta, Zhang, Yanyu, Cao, Haiyan, He, Qiyuan, Chao, Min, Liu, Boxuan, Cao, Qingze, Wang, Jianhao, Jiao, Yang, Hu, Yaqin, Han, Liying, Zhang, Yong, Huang, Hua, Uhrbom, Lene, Betsholtz, Christer, Wang, Liang, Dimberg, Anna, Zhang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410070/
https://www.ncbi.nlm.nih.gov/pubmed/34228647
http://dx.doi.org/10.1172/jci.insight.150861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410070/
https://www.ncbi.nlm.nih.gov/pubmed/34228647
http://dx.doi.org/10.1172/jci.insight.150861

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