12-Lipoxygenase governs the innate immune pathogenesis of islet inflammation and autoimmune diabetes

Macrophages and related myeloid cells are innate immune cells that participate in the early islet inflammation of type 1 diabetes (T1D). The enzyme 12-lipoxygenase (12-LOX) catalyzes the formation of proinflammatory eicosanoids, but its role and mechanisms in myeloid cells in the pathogenesis of isl...

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Detalles Bibliográficos
Autores principales: Kulkarni, Abhishek, Pineros, Annie R., Walsh, Melissa A., Casimiro, Isabel, Ibrahim, Sara, Hernandez-Perez, Marimar, Orr, Kara S., Glenn, Lindsey, Nadler, Jerry L., Morris, Margaret A., Tersey, Sarah A., Mirmira, Raghavendra G., Anderson, Ryan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410073/
https://www.ncbi.nlm.nih.gov/pubmed/34128835
http://dx.doi.org/10.1172/jci.insight.147812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410073/
https://www.ncbi.nlm.nih.gov/pubmed/34128835
http://dx.doi.org/10.1172/jci.insight.147812

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