Modulation of the effects of class Ib antiarrhythmics on cardiac Na(V)1.5-encoded channels by accessory Na(V)β subunits

Native myocardial voltage-gated sodium (Na(V)) channels function in macromolecular complexes comprising a pore-forming (α) subunit and multiple accessory proteins. Here, we investigated the impact of accessory Na(V)β1 and Na(V)β3 subunits on the functional effects of 2 well-known class Ib antiarrhyt...

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Detalles Bibliográficos
Autores principales: Zhu, Wandi, Wang, Wei, Angsutararux, Paweorn, Mellor, Rebecca L., Isom, Lori L., Nerbonne, Jeanne M., Silva, Jonathan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410097/
https://www.ncbi.nlm.nih.gov/pubmed/34156986
http://dx.doi.org/10.1172/jci.insight.143092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410097/
https://www.ncbi.nlm.nih.gov/pubmed/34156986
http://dx.doi.org/10.1172/jci.insight.143092

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