Cargando…

Modulation of the effects of class Ib antiarrhythmics on cardiac Na(V)1.5-encoded channels by accessory Na(V)β subunits

Native myocardial voltage-gated sodium (Na(V)) channels function in macromolecular complexes comprising a pore-forming (α) subunit and multiple accessory proteins. Here, we investigated the impact of accessory Na(V)β1 and Na(V)β3 subunits on the functional effects of 2 well-known class Ib antiarrhyt...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Wandi, Wang, Wei, Angsutararux, Paweorn, Mellor, Rebecca L., Isom, Lori L., Nerbonne, Jeanne M., Silva, Jonathan R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410097/ https://www.ncbi.nlm.nih.gov/pubmed/34156986 http://dx.doi.org/10.1172/jci.insight.143092

Ejemplares similares

Conformations of voltage-sensing domain III differentially define Na(V) channel closed- and open-state inactivation
por: Angsutararux, Paweorn, et al.
Publicado: (2021)

Mechanisms of noncovalent β subunit regulation of Na(V) channel gating
por: Zhu, Wandi, et al.
Publicado: (2017)

Molecular Pathology of Sodium Channel Beta-Subunit Variants
por: Angsutararux, Paweorn, et al.
Publicado: (2021)

A Molecularly Detailed Na(V)1.5 Model Reveals a New Class I Antiarrhythmic Target
por: Moreno, Jonathan D., et al.
Publicado: (2019)

Na(+) Channel β Subunits: Overachievers of the Ion Channel Family
por: Brackenbury, William J., et al.
Publicado: (2011)

Differential regulation of cardiac sodium channels by intracellular fibroblast growth factors
por: Angsutararux, Paweorn, et al.
Publicado: (2023)

Comparing human iPSC-cardiomyocytes versus HEK293T cells unveils disease-causing effects of Brugada mutation A735V of Na(V)1.5 sodium channels
por: de la Roche, Jeanne, et al.
Publicado: (2019)

Subcellular dynamics and functional activity of the cleaved intracellular domain of the Na(+) channel β1 subunit
por: Haworth, Alexander S., et al.
Publicado: (2022)

Intrinsic mechanisms in the gating of resurgent Na(+) currents
por: Ransdell, Joseph L, et al.
Publicado: (2022)

Conservation and divergence in NaChBac and Na(V)1.7 pharmacology reveals novel drug interaction mechanisms
por: Zhu, Wandi, et al.
Publicado: (2020)

Mechanical dysfunction of the sarcomere induced by a pathogenic mutation in troponin T drives cellular adaptation
por: Clippinger, Sarah R., et al.
Publicado: (2021)

Enhanced Late Na and Ca Currents as Effective Antiarrhythmic Drug Targets
por: Karagueuzian, Hrayr S., et al.
Publicado: (2017)

Inhibitory effects of class I antiarrhythmic agents on Na(+) and Ca(2+) currents of human iPS cell-derived cardiomyocytes
por: Yonemizu, Sayaka, et al.
Publicado: (2019)

Using fluorescence to understand β subunit–Na(V) channel interactions
por: Barro-Soria, Rene, et al.
Publicado: (2017)

Proteomic and functional mapping of cardiac Na(V)1.5 channel phosphorylation sites
por: Lorenzini, Maxime, et al.
Publicado: (2021)

Chemotherapy-Induced Cardiotoxicity: Overview of the Roles of Oxidative Stress
por: Angsutararux, Paweorn, et al.
Publicado: (2015)

Therapeutic potential for phenytoin: targeting Na(v)1.5 sodium channels to reduce migration and invasion in metastatic breast cancer
por: Yang, Ming, et al.
Publicado: (2012)

Antillatoxin is a sodium channel activator that displays unique efficacy in heterologously expressed rNa(v)1.2, rNa(v)1.4 and rNa(v)1.5 alpha subunits
por: Cao, Zhengyu, et al.
Publicado: (2010)

Acidosis Differentially Modulates Inactivation in Na(V)1.2, Na(V)1.4, and Na(V)1.5 Channels
por: Vilin, Yury Y., et al.
Publicado: (2012)

Structural basis of cytoplasmic Na(V)1.5 and Na(V)1.4 regulation
por: Nathan, Sara, et al.
Publicado: (2020)

Complementary roles of murine Na(V)1.7, Na(V)1.8 and Na(V)1.9 in acute itch signalling
por: Kühn, Helen, et al.
Publicado: (2020)

Na(v)1.7 and Na(v)1.8: Role in the pathophysiology of pain
por: Hameed, Shaila
Publicado: (2019)

β subunit affects Na(+) and K(+) affinities of Na(+)/K(+)-ATPase: Na(+) and K(+) affinities of a hybrid Na(+)/K(+)-ATPase composed of insect α and mammalian β subunits
por: Homareda, Haruo, et al.
Publicado: (2022)

No transcriptional evidence for active Na(v) channels in two classes of cancer cell
por: Hompoonsup, Supanida, et al.
Publicado: (2019)

Neuropathic pain develops normally in mice lacking both Na(v)1.7 and Na(v)1.8
por: Nassar, Mohammed A, et al.
Publicado: (2005)

Epithelial Na Channels : Why All the Subunits?
por: Palmer, Lawrence G.
Publicado: (1997)

Tuning of the Na,K-ATPase by the beta subunit
por: Hilbers, Florian, et al.
Publicado: (2016)

Transcriptional regulators of Na,K-ATPase subunits
por: Li, Zhiqin, et al.
Publicado: (2015)

The trafficking of Na(V)1.8
por: Swanwick, Richard S., et al.
Publicado: (2010)

Cold sensing by Na(V)1.8-positive and Na(V)1.8-negative sensory neurons
por: Luiz, A. P., et al.
Publicado: (2019)

Ciguatoxins Evoke Potent CGRP Release by Activation of Voltage-Gated Sodium Channel Subtypes Na(V)1.9, Na(V)1.7 and Na(V)1.1
por: Touska, Filip, et al.
Publicado: (2017)

Depolarization of the conductance-voltage relationship in the Na(V)1.5 mutant, E1784K, is due to altered fast inactivation
por: Peters, Colin H., et al.
Publicado: (2017)

Ginsenoside Rb1 exerts antiarrhythmic effects by inhibiting I(Na) and I(CaL) in rabbit ventricular myocytes
por: Liu, Zhipei, et al.
Publicado: (2019)

Superconcentrated NaFSA–KFSA Aqueous Electrolytes for 2 V-Class Dual-Ion Batteries
por: Hosaka, Tomooki, et al.
Publicado: (2022)

Initiation and outcomes with Class Ic antiarrhythmic drug therapy
por: Gao, Xu, et al.
Publicado: (2017)

ARumenamides: A novel class of potential antiarrhythmic compounds
por: Abdelsayed, Mena, et al.
Publicado: (2022)

Class III Antiarrhythmics and Periprocedural Torsades de Pointes
por: Font, Cristina M., et al.
Publicado: (2023)

Variable patterns of mutation density among Na(V)1.1, Na(V)1.2 and Na(V)1.6 point to channel-specific functional differences associated with childhood epilepsy
por: Encinas, Alejandra C., et al.
Publicado: (2020)

Crystal Structure and Molecular Imaging of the Na(v) Channel β3 Subunit Indicates a Trimeric Assembly
por: Namadurai, Sivakumar, et al.
Publicado: (2014)

Functional modulation of the human voltage-gated sodium channel Na(V)1.8 by auxiliary β subunits
por: Nevin, S. T., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_730jdf4cec4c27cn8psq78ts6t