Lenvatinib halts aortic aneurysm growth by restoring smooth muscle cell contractility

Abdominal aortic aneurysm (AAA) is a disease with high morbidity and mortality, especially when ruptured. The rationale of this study was to evaluate the repurposing of lenvatinib, a multi–tyrosine kinase inhibitor, in limiting experimental AAA growth targeting vascular smooth muscle cells (VSMCs) a...

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Detalles Bibliográficos
Autores principales: Busch, Albert, Pauli, Jessica, Winski, Greg, Bleichert, Sonja, Chernogubova, Ekaterina, Metschl, Susanne, Winter, Hanna, Trenner, Matthias, Wiegering, Armin, Otto, Christoph, Fischer, Johannes, Reiser, Judith, Werner, Julia, Roy, Joy, Brostjan, Christine, Knappich, Christoph, Eckstein, Hans-Henning, Paloschi, Valentina, Maegdefessel, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410098/
https://www.ncbi.nlm.nih.gov/pubmed/34185710
http://dx.doi.org/10.1172/jci.insight.140364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410098/
https://www.ncbi.nlm.nih.gov/pubmed/34185710
http://dx.doi.org/10.1172/jci.insight.140364

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