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Predicted pH-dependent stability of SARS-CoV-2 spike protein trimer from interfacial acidic groups

Transition between receptor binding domain (RBD) up and down forms of the SARS-CoV-2 spike protein trimer is coupled to receptor binding and is one route by which variants can alter viral properties. It is becoming apparent that key roles in the transition are played by pH and a more compact closed...

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Detalles Bibliográficos
Autores principales: Lobo, Vanessa R., Warwicker, Jim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410215/
https://www.ncbi.nlm.nih.gov/pubmed/34490059
http://dx.doi.org/10.1016/j.csbj.2021.08.049