3D-QSAR-Based Pharmacophore Modeling, Virtual Screening, and Molecular Docking Studies for Identification of Tubulin Inhibitors with Potential Anticancer Activity

In this study, we aimed to develop a pharmacophore-based three-dimensional quantitative structure activity relationship (3D-QSAR) for a set including sixty-two cytotoxic quinolines (1-62) as anticancer agents with tubulin inhibitory activity. A total of 279 pharmacophore hypotheses were generated ba...

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Detalles Bibliográficos
Autores principales: Mirzaei, Salimeh, Ghodsi, Razieh, Hadizadeh, Farzin, Sahebkar, Amirhossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410400/
https://www.ncbi.nlm.nih.gov/pubmed/34485522
http://dx.doi.org/10.1155/2021/6480804

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410400/
https://www.ncbi.nlm.nih.gov/pubmed/34485522
http://dx.doi.org/10.1155/2021/6480804

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