Dactinomycin induces complete remission associated with nucleolar stress response in relapsed/refractory NPM1-mutated AML

Acute myeloid leukemia (AML) with mutated NPM1 accounts for one-third of newly diagnosed AML. Despite recent advances, treatment of relapsed/refractory NPM1-mutated AML remains challenging, with the majority of patients eventually dying due to disease progression. Moreover, the prognosis is particul...

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Detalles Bibliográficos
Autores principales: Gionfriddo, Ilaria, Brunetti, Lorenzo, Mezzasoma, Federica, Milano, Francesca, Cardinali, Valeria, Ranieri, Roberta, Venanzi, Alessandra, Pierangeli, Sara, Vetro, Calogero, Spinozzi, Giulio, Dorillo, Erica, Wu, Hsin Chieh, Berthier, Caroline, Ciurnelli, Raffaella, Griffin, Melanie J., Jennings, Claire E., Tiacci, Enrico, Sportoletti, Paolo, Falzetti, Franca, de Thé, Hugues, Veal, Gareth J., Martelli, Maria Paola, Falini, Brunangelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410589/
https://www.ncbi.nlm.nih.gov/pubmed/33654209
http://dx.doi.org/10.1038/s41375-021-01192-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410589/
https://www.ncbi.nlm.nih.gov/pubmed/33654209
http://dx.doi.org/10.1038/s41375-021-01192-7

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