The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8

Pyroptosis is a form of regulated cell death mediated by gasdermin family members, among which the function of GSDMC has not been clearly described. Herein, we demonstrate that the metabolite α-ketoglutarate (α-KG) induces pyroptosis through caspase-8-mediated cleavage of GSDMC. Treatment with DM-αK...

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Detalles Bibliográficos
Autores principales: Zhang, Jia-yuan, Zhou, Bo, Sun, Ru-yue, Ai, Yuan-li, Cheng, Kang, Li, Fu-nan, Wang, Bao-rui, Liu, Fan-jian, Jiang, Zhi-hong, Wang, Wei-jia, Zhou, Dawang, Chen, Hang-zi, Wu, Qiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410789/
https://www.ncbi.nlm.nih.gov/pubmed/34012073
http://dx.doi.org/10.1038/s41422-021-00506-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410789/
https://www.ncbi.nlm.nih.gov/pubmed/34012073
http://dx.doi.org/10.1038/s41422-021-00506-9

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