Molecular modelling approaches predicted 1,2,3-triazolyl ester of ketorolac (15K) to be a novel allosteric modulator of the oncogenic kinase PAK1

P21-activated kinases (PAKs) are serine/threonine protein kinase which have six different isoforms (PAK1–6). Of those, PAK1 is overexpressed in many cancers and considered to be a major chemotherapeutic target. Most of the developed PAK1 inhibitor drugs work as pan-PAK inhibitors and show undesirabl...

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Detalles Bibliográficos
Autores principales: Shahinozzaman, Md, Ahmed, Sinthyia, Emran, Rashiduzzaman, Tawata, Shinkichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410820/
https://www.ncbi.nlm.nih.gov/pubmed/34471161
http://dx.doi.org/10.1038/s41598-021-96817-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410820/
https://www.ncbi.nlm.nih.gov/pubmed/34471161
http://dx.doi.org/10.1038/s41598-021-96817-3

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