Cyclooxygenase-2 Inhibitor Parecoxib Was Disclosed as a PPAR-γ Agonist by In Silico and In Vitro Assay

In a search for effective PPAR-γ agonists, 110 clinical drugs were screened via molecular docking, and 9 drugs, including parecoxib, were selected for subsequent biological evaluation. Molecular docking of parecoxib to the ligand-binding domain of PPAR-γ showed high binding affinity and relevant bin...

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Detalles Bibliográficos
Autores principales: Xiao, Bin, Li, Dan-dan, Wang, Ying, Kim, Eun La, Zhao, Na, Jin, Shang-Wu, Bai, Dong-Hao, Sun, Li-Dong, Jung, Jee H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411028/
https://www.ncbi.nlm.nih.gov/pubmed/33883322
http://dx.doi.org/10.4062/biomolther.2021.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411028/
https://www.ncbi.nlm.nih.gov/pubmed/33883322
http://dx.doi.org/10.4062/biomolther.2021.008

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