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Cyclooxygenase-2 Inhibitor Parecoxib Was Disclosed as a PPAR-γ Agonist by In Silico and In Vitro Assay

In a search for effective PPAR-γ agonists, 110 clinical drugs were screened via molecular docking, and 9 drugs, including parecoxib, were selected for subsequent biological evaluation. Molecular docking of parecoxib to the ligand-binding domain of PPAR-γ showed high binding affinity and relevant bin...

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Detalles Bibliográficos
Autores principales:	Xiao, Bin, Li, Dan-dan, Wang, Ying, Kim, Eun La, Zhao, Na, Jin, Shang-Wu, Bai, Dong-Hao, Sun, Li-Dong, Jung, Jee H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Society of Applied Pharmacology 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411028/ https://www.ncbi.nlm.nih.gov/pubmed/33883322 http://dx.doi.org/10.4062/biomolther.2021.008

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