Cargando…
Multiple basic amino acids in the cleavage site of H7N9 hemagglutinin contribute to high virulence in mice
BACKGROUND: Avian influenza A (H7N9) virus has caused more than 1,500 cases of human infection since its emergence in early 2013. Displaying little or no pathogenicity in poultry, but a 40% case-fatality rate in humans, five waves of H7N9 human infections occurred in China during 2013–2017, caused s...
Autores principales: | Song, Wenjun, Huang, Xiaofeng, Guan, Wenda, Chen, Pin, Wang, Pui, Zheng, Min, Li, Zhengtu, Wang, Yutao, Yang, Zifeng, Chen, Honglin, Wang, Xinhua |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411188/ https://www.ncbi.nlm.nih.gov/pubmed/34527306 http://dx.doi.org/10.21037/jtd-21-226 |
Ejemplares similares
-
Non-basic amino acids in the hemagglutinin proteolytic cleavage site of a European H9N2 avian influenza virus modulate virulence in turkeys
por: Blaurock, Claudia, et al.
Publicado: (2020) -
First genome report and analysis of chicken H7N9 influenza viruses with poly-basic amino acids insertion in the hemagglutinin cleavage site
por: Chen, Jidang, et al.
Publicado: (2017) -
Combined insertion of basic and non-basic amino acids at hemagglutinin cleavage site of highly pathogenic H7N9 virus promotes replication and pathogenicity in chickens and mice
por: Zhou, Aobaixue, et al.
Publicado: (2022) -
Antigenic Drift of the Hemagglutinin from an Influenza A (H1N1) pdm09 Clinical Isolate Increases its Pathogenicity In Vitro
por: Xing, Lei, et al.
Publicado: (2021) -
Genetic insight of the H5N1 hemagglutinin cleavage site
por: Guo, XiaoLi, et al.
Publicado: (2007)