Deletion of immunomodulatory genes as a novel approach to oncolytic vaccinia virus development

Vaccinia virus (VV) has emerged as a promising platform for oncolytic virotherapy. Many clinical VV candidates, such as the double-deleted VV, vvDD, are engineered with deletions that enhance viral tumor selectivity based on cellular proliferation rates. An alternative approach is to exploit the dam...

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Detalles Bibliográficos
Autores principales: Ho, Tiffany Y., Mealiea, David, Okamoto, Lili, Stojdl, David F., McCart, J. Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411212/
https://www.ncbi.nlm.nih.gov/pubmed/34514091
http://dx.doi.org/10.1016/j.omto.2021.05.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411212/
https://www.ncbi.nlm.nih.gov/pubmed/34514091
http://dx.doi.org/10.1016/j.omto.2021.05.007

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