A three-pocket model for substrate coordination and selectivity by the nucleotide sugar transporters SLC35A1 and SLC35A2

The CMP-sialic acid transporter SLC35A1 and UDP-galactose transporter SLC35A2 are two well-characterized nucleotide sugar transporters with distinctive substrate specificities. Mutations in either induce congenital disorders of glycosylation. Despite the biomedical relevance, mechanisms of substrate...

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Detalles Bibliográficos
Autores principales: Li, Danyang, Mukhopadhyay, Somshuvra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411240/
https://www.ncbi.nlm.nih.gov/pubmed/34384782
http://dx.doi.org/10.1016/j.jbc.2021.101069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411240/
https://www.ncbi.nlm.nih.gov/pubmed/34384782
http://dx.doi.org/10.1016/j.jbc.2021.101069

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