Development and validation of assays for the quantification of β-D-N(4)-hydroxycytidine in human plasma and β-D-N(4)-hydroxycytidine-triphosphate in peripheral blood mononuclear cell lysates

The novel antiviral prodrug molnupiravir is under evaluation for the treatment of SARS-CoV-2. Molnupiravir is converted to β-D-N(4)-hydroxycytidine (NHC), which is the primary form found in systemic circulation. β-D-N(4)-hydroxycytidine-triphosphate (NHCtp) is the bioactive anabolite produced intrac...

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Detalles Bibliográficos
Autores principales: Parsons, Teresa L., Kryszak, Lindsay A., Marzinke, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411588/
https://www.ncbi.nlm.nih.gov/pubmed/34555541
http://dx.doi.org/10.1016/j.jchromb.2021.122921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411588/
https://www.ncbi.nlm.nih.gov/pubmed/34555541
http://dx.doi.org/10.1016/j.jchromb.2021.122921

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