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Development and validation of assays for the quantification of β-D-N(4)-hydroxycytidine in human plasma and β-D-N(4)-hydroxycytidine-triphosphate in peripheral blood mononuclear cell lysates
The novel antiviral prodrug molnupiravir is under evaluation for the treatment of SARS-CoV-2. Molnupiravir is converted to β-D-N(4)-hydroxycytidine (NHC), which is the primary form found in systemic circulation. β-D-N(4)-hydroxycytidine-triphosphate (NHCtp) is the bioactive anabolite produced intrac...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier B.V.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411588/ https://www.ncbi.nlm.nih.gov/pubmed/34555541 http://dx.doi.org/10.1016/j.jchromb.2021.122921 |