The genetic consequences of dog breed formation—Accumulation of deleterious genetic variation and fixation of mutations associated with myxomatous mitral valve disease in cavalier King Charles spaniels

Selective breeding for desirable traits in strictly controlled populations has generated an extraordinary diversity in canine morphology and behaviour, but has also led to loss of genetic variation and random entrapment of disease alleles. As a consequence, specific diseases are now prevalent in cer...

Descripción completa

Detalles Bibliográficos
Autores principales: Axelsson, Erik, Ljungvall, Ingrid, Bhoumik, Priyasma, Conn, Laura Bas, Muren, Eva, Ohlsson, Åsa, Olsen, Lisbeth Høier, Engdahl, Karolina, Hagman, Ragnvi, Hanson, Jeanette, Kryvokhyzha, Dmytro, Pettersson, Mats, Grenet, Olivier, Moggs, Jonathan, Del Rio-Espinola, Alberto, Epe, Christian, Taillon, Bruce, Tawari, Nilesh, Mane, Shrinivas, Hawkins, Troy, Hedhammar, Åke, Gruet, Philippe, Häggström, Jens, Lindblad-Toh, Kerstin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8412370/
https://www.ncbi.nlm.nih.gov/pubmed/34473707
http://dx.doi.org/10.1371/journal.pgen.1009726

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8412370/
https://www.ncbi.nlm.nih.gov/pubmed/34473707
http://dx.doi.org/10.1371/journal.pgen.1009726

Ejemplares similares