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The Effect of Core Replacement on S64315, a Selective MCL-1 Inhibitor, and Its Analogues
[Image: see text] Following the identification of thieno[2,3-d]pyrimidine-based selective and potent inhibitors of MCL-1, we explored the effect of core swapping at different levels of advancement. During hit-to-lead optimization, X-ray-guided S-N replacement in the core provided a new vector, whose...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8412899/ https://www.ncbi.nlm.nih.gov/pubmed/34497901 http://dx.doi.org/10.1021/acsomega.1c02595 |