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Computational Analysis of the Nicotine Oxidoreductase Mechanism by the ONIOM Method

[Image: see text] Nicotine oxidoreductase (NicA2) is a monoamine oxidase (MAO)-based flavoenzyme that catalyzes the oxidation of S-nicotine into N-methylmyosmine. Due to its nanomolar binding affinity toward nicotine, it is seen as an ideal candidate for the treatment of nicotine addiction. Based on...

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Detalles Bibliográficos
Autor principal: Yildiz, Ibrahim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8412962/
https://www.ncbi.nlm.nih.gov/pubmed/34497931
http://dx.doi.org/10.1021/acsomega.1c03357