Cancer cells escape p53’s tumor suppression through ablation of ZDHHC1-mediated p53 palmitoylation

The inactivation of tumor-suppressor genes contributes heavily to oncogenesis. The mutation of TP53 has been well-studied and recognized as a major factor in the development of tumors. Yet other means of p53 inactivation has not been well-elucidated. We previously identified a hypermethylated gene Z...

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Detalles Bibliográficos
Autores principales: Tang, Jun, Peng, Weiyan, Feng, Yixiao, Le, Xin, Wang, Kang, Xiang, Qin, Li, Lili, Wang, Yan, Xu, Can, Mu, Junhao, Xu, Ke, Ji, Ping, Tao, Qian, Huang, Ailong, Deng, Chu-Xia, Lin, Yong, Xiang, Tingxiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413129/
https://www.ncbi.nlm.nih.gov/pubmed/34282274
http://dx.doi.org/10.1038/s41388-021-01949-5

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