On-target IgG hexamerisation driven by a C-terminal IgM tail-piece fusion variant confers augmented complement activation

The majority of depleting monoclonal antibody (mAb) drugs elicit responses via Fc-FcγR and Fc-C1q interactions. Optimal C1q interaction is achieved through hexameric Fc:Fc interactions at the target cell surface. Herein is described an approach to exploit the tailpiece of the naturally multimeric Ig...

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Detalles Bibliográficos
Autores principales: Sopp, Joshua M., Peters, Shirley J., Rowley, Tania F., Oldham, Robert J., James, Sonya, Mockridge, Ian, French, Ruth R., Turner, Alison, Beers, Stephen A., Humphreys, David P., Cragg, Mark S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413284/
https://www.ncbi.nlm.nih.gov/pubmed/34475514
http://dx.doi.org/10.1038/s42003-021-02513-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413284/
https://www.ncbi.nlm.nih.gov/pubmed/34475514
http://dx.doi.org/10.1038/s42003-021-02513-3

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