Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer

The most common events in breast cancer (BC) involve chromosome arm losses and gains. Here we describe identification of 1089 gene-centric common insertion sites (gCIS) from transposon-based screens in 8 mouse models of BC. Some gCIS are driver-specific, others driver non-specific, and still others...

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Detalles Bibliográficos
Autores principales: Schachter, Nathan F., Adams, Jessica R., Skowron, Patryk, Kozma, Katelyn. J., Lee, Christian A., Raghuram, Nandini, Yang, Joanna, Loch, Amanda J., Wang, Wei, Kucharczuk, Aaron, Wright, Katherine L., Quintana, Rita M., An, Yeji, Dotzko, Daniel, Gorman, Jennifer L., Wojtal, Daria, Shah, Juhi S., Leon-Gomez, Paul, Pellecchia, Giovanna, Dupuy, Adam J., Perou, Charles M., Ben-Porath, Ittai, Karni, Rotem, Zacksenhaus, Eldad, Woodgett, Jim R., Done, Susan J., Garzia, Livia, Sorana Morrissy, A., Reimand, Jüri, Taylor, Michael D., Egan, Sean E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413298/
https://www.ncbi.nlm.nih.gov/pubmed/34475389
http://dx.doi.org/10.1038/s41467-021-25467-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413298/
https://www.ncbi.nlm.nih.gov/pubmed/34475389
http://dx.doi.org/10.1038/s41467-021-25467-w

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