Oncolytic herpes virus G47Δ works synergistically with CTLA-4 inhibition via dynamic intratumoral immune modulation

Oncolytic virus therapy can increase the immunogenicity of tumors and remodel the immunosuppressive tumor microenvironment, leading to an increased antitumor response to immune-checkpoint inhibitors. Here, we investigated the therapeutic potential of G47Δ, a third-generation oncolytic herpes simplex...

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Detalles Bibliográficos
Autores principales: Sugawara, Kotaro, Iwai, Miwako, Ito, Hirotaka, Tanaka, Minoru, Seto, Yasuyuki, Todo, Tomoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413837/
https://www.ncbi.nlm.nih.gov/pubmed/34514094
http://dx.doi.org/10.1016/j.omto.2021.05.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413837/
https://www.ncbi.nlm.nih.gov/pubmed/34514094
http://dx.doi.org/10.1016/j.omto.2021.05.004

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