Molecular mechanisms of centipede toxin SsTx-4 inhibition of inwardly rectifying potassium channels

Inwardly rectifying potassium channels (Kirs) are important drug targets, with antagonists for the Kir1.1, Kir4.1, and pancreatic Kir6.2/SUR1 channels being potential drug candidates for treating hypertension, depression, and diabetes, respectively. However, few peptide toxins acting on Kirs are ide...

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Detalles Bibliográficos
Autores principales: Tang, Dongfang, Xu, Jiahui, Li, Yinping, Zhao, Piao, Kong, Xiangjin, Hu, Haoliang, Liang, Songping, Tang, Cheng, Liu, Zhonghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413892/
https://www.ncbi.nlm.nih.gov/pubmed/34391777
http://dx.doi.org/10.1016/j.jbc.2021.101076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413892/
https://www.ncbi.nlm.nih.gov/pubmed/34391777
http://dx.doi.org/10.1016/j.jbc.2021.101076

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