Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile

Broadly neutralizing antibodies (bnAbs) against HIV-1 are frequently associated with the presence of autoreactivity/polyreactivity, a property that can limit their use as therapeutic agents. The bnAb 4E10, targeting the conserved Membrane proximal external region (MPER) of HIV-1, displays almost pan...

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Detalles Bibliográficos
Autores principales: Rujas, Edurne, Leaman, Daniel P., Insausti, Sara, Carravilla, Pablo, García-Porras, Miguel, Largo, Eneko, Morillo, Izaskun, Sánchez-Eugenia, Rubén, Zhang, Lei, Cui, Hong, Iloro, Ibon, Elortza, Félix, Julien, Jean-Philippe, Eggeling, Christian, Zwick, Michael B., Caaveiro, Jose M.M., Nieva, José L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413895/
https://www.ncbi.nlm.nih.gov/pubmed/34505005
http://dx.doi.org/10.1016/j.isci.2021.102987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413895/
https://www.ncbi.nlm.nih.gov/pubmed/34505005
http://dx.doi.org/10.1016/j.isci.2021.102987

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