Samotolisib Attenuates Acute Liver Injury Through Inhibiting Caspase-11-Mediated Pyroptosis Via Regulating E3 Ubiquitin Ligase Nedd4

Acute liver injury (ALI) is associated with poor survival in patients with sepsis. During sepsis, the liver is the main site of bacterial endotoxin-induced inflammation. Lipopolysaccharide (LPS) promotes caspase-4/5/11 activation, leading to pyroptosis, a major sepsis driver. This study aimed to ide...

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Detalles Bibliográficos
Autores principales: Zhao, Yang-Yang, Wu, Dong-Ming, He, Miao, Zhang, Feng, Zhang, Ting, Liu, Teng, Li, Jin, Li, Li, Xu, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414251/
https://www.ncbi.nlm.nih.gov/pubmed/34483936
http://dx.doi.org/10.3389/fphar.2021.726198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414251/
https://www.ncbi.nlm.nih.gov/pubmed/34483936
http://dx.doi.org/10.3389/fphar.2021.726198

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