Cargando…

The antioxidant N-acetylcysteine promotes immune response and inhibits epithelial-mesenchymal transition to alleviate pulmonary fibrosis in chronic obstructive pulmonary disease by suppressing the VWF/p38 MAPK axis

BACKGROUND/AIM: N-Acetylcysteine (NAC) demonstrates applications in the prevention of exacerbation of chronic obstructive pulmonary disease (COPD). COPD is often characterized by fibrosis of the small airways. This study aims at investigating the physiological mechanisms by which NAC might mediate t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Lanlan, Xu, Fei, Kang, Xiuhua, Zhou, Jing, Yao, Qinqin, Lin, Yang, Zhang, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414683/ https://www.ncbi.nlm.nih.gov/pubmed/34479474 http://dx.doi.org/10.1186/s10020-021-00342-y

Ejemplares similares

The ADAMTS13–VWF axis is dysregulated in chronic thromboembolic pulmonary hypertension
por: Newnham, Michael, et al.
Publicado: (2019)

Effects and mechanisms of pirfenidone, prednisone and acetylcysteine on pulmonary fibrosis in rat idiopathic pulmonary fibrosis models
por: Yu, Wencheng, et al.
Publicado: (2016)

p38 MAPK signaling in chronic obstructive pulmonary disease pathogenesis and inhibitor therapeutics
por: Ahmadi, Ali, et al.
Publicado: (2023)

The ER Stress/UPR Axis in Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis
por: Aghaei, Mahmoud, et al.
Publicado: (2020)

538. The Role of N-acetylcysteine on Post Covid-19 Pulmonary Fibrosis
por: Demot, Bernard, et al.
Publicado: (2021)

N-acetylcysteine in the Management of Acute Exacerbation of Chronic Obstructive Pulmonary Disease
por: Ansari, Sheeba F, et al.
Publicado: (2019)

Loss of FOXM1 in macrophages promotes pulmonary fibrosis by activating p38 MAPK signaling pathway
por: Goda, Chinmayee, et al.
Publicado: (2020)

Dexmedetomidine alleviates pulmonary fibrosis through the ADORA2B-Mediated MAPK signaling pathway
por: Lai, Xiaofan, et al.
Publicado: (2023)

N-Acetylcysteine attenuated pulmonary fibrosis induced by bleomycin via immunomodulation responses
por: Maghsadi, Zahra, et al.
Publicado: (2023)

Effects of N-Acetylcysteine in Ozone-Induced Chronic Obstructive Pulmonary Disease Model
por: Li, Feng, et al.
Publicado: (2013)

Efficacy and Safety of N-Acetylcysteine for Chronic Obstructive Pulmonary Disease and Chronic Bronchitis
por: Zhang, Li, et al.
Publicado: (2022)

Enhanced VWF clearance in low VWF pathogenesis: limitations of the VWFpp/VWF:Ag ratio and clinical significance
por: Doherty, Dearbhla, et al.
Publicado: (2022)

Targeting Mechanosensitive Piezo1 Alleviated Renal Fibrosis Through p38MAPK-YAP Pathway
por: Fu, Yuanyuan, et al.
Publicado: (2021)

N-acetylcysteine tiherapeutically protects against pulmonary fibrosis in a mouse model of silicosis
por: Huang, Huaping, et al.
Publicado: (2019)

Efficacy of N-Acetylcysteine in Idiopathic Pulmonary Fibrosis: A Systematic Review and Meta-Analysis
por: Sun, Tong, et al.
Publicado: (2016)

Comparison of Pharmacokinetics and Anti-Pulmonary Fibrosis-Related Effects of Sulforaphane and Sulforaphane N-acetylcysteine
por: Son, Eun Suk, et al.
Publicado: (2021)

The efficacy of N-acetylcysteine in chronic obstructive pulmonary disease patients: a meta-analysis
por: Huang, Chienhsiu, et al.
Publicado: (2023)

Pharmacological treatment of idiopathic pulmonary fibrosis – preclinical and clinical studies of pirfenidone, nintedanib, and N-acetylcysteine
por: Myllärniemi, Marjukka, et al.
Publicado: (2015)

Efficacy and safety profile of mucolytic/antioxidant agents in chronic obstructive pulmonary disease: a comparative analysis across erdosteine, carbocysteine, and N-acetylcysteine
por: Rogliani, Paola, et al.
Publicado: (2019)

microRNA-186 in extracellular vesicles from bone marrow mesenchymal stem cells alleviates idiopathic pulmonary fibrosis via interaction with SOX4 and DKK1
por: Zhou, Jing, et al.
Publicado: (2021)

Baseline vWF factor predicts the development of elevated pulmonary artery pressure in systemic sclerosis
por: Barnes, Theresa, et al.
Publicado: (2012)

VWF springs into action
por: Wells, William A.
Publicado: (2006)

The EGFR-ADAM17 Axis in Chronic Obstructive Pulmonary Disease and Cystic Fibrosis Lung Pathology
por: Stolarczyk, Marta, et al.
Publicado: (2018)

Necrostatin-1 Alleviates Bleomycin-Induced Pulmonary Fibrosis and Extracellular Matrix Expression in Interstitial Pulmonary Fibrosis
por: Mou, Fanghong, et al.
Publicado: (2020)

Efficacy and safety of N-acetylcysteine therapy for idiopathic pulmonary fibrosis: An updated systematic review and meta-analysis
por: Feng, Fanchao, et al.
Publicado: (2019)

Beneficial effects of N-acetylcysteine on protease-antiprotease balance in attenuating bleomycin-induced pulmonary fibrosis in rats
por: Kulshrestha, Ritu, et al.
Publicado: (2020)

Update on the pathological processes, molecular biology, and clinical utility of N-acetylcysteine in chronic obstructive pulmonary disease
por: Tse, Hoi Nam, et al.
Publicado: (2014)

Riociguat inhibits ultra‐large VWF string formation on pulmonary artery endothelial cells from chronic thromboembolic pulmonary hypertension patients
por: Jujo Sanada, Takayuki, et al.
Publicado: (2022)

Pterostilbene alleviates pulmonary fibrosis by regulating ASIC2
por: Peng, Yanfang, et al.
Publicado: (2021)

Pharmacological inhibition of MDM4 alleviates pulmonary fibrosis
por: Mei, Qianru, et al.
Publicado: (2023)

BDNF/TrkB axis activation promotes epithelial–mesenchymal transition in idiopathic pulmonary fibrosis
por: Cherubini, Emanuela, et al.
Publicado: (2017)

Combination of Niclosamide and Pirfenidone Alleviates Pulmonary Fibrosis by Inhibiting Oxidative Stress and MAPK/Nf-κB and STATs Regulated Genes
por: Wanas, Hanaa, et al.
Publicado: (2023)

Pretreatment with valproic acid alleviates pulmonary fibrosis through epithelial–mesenchymal transition inhibition in vitro and in vivo
por: Chen, Lin, et al.
Publicado: (2021)

Does pulmonary rehabilitation alleviate depression in older patients with chronic obstructive pulmonary disease
por: Alsaraireh, Faris A., et al.
Publicado: (2017)

Chinese herbal medicines compared with N-acetylcysteine for the treatment of idiopathic pulmonary fibrosis: Protocol for a systematic review
por: Guo, Jing, et al.
Publicado: (2018)

Comparison of Longevity in Patients with Idiopathic Pulmonary Fibrosis Using Pirfenidone Versus Triple Therapy with Prednisolone, Azathioprine, and Acetylcysteine
por: Asl, Mobin Soleimanian, et al.
Publicado: (2023)

Efficacy of N-acetylcysteine plus pirfenidone in the treatment of idiopathic pulmonary fibrosis: a systematic review and meta-analysis
por: Zhang, Xiu-Li, et al.
Publicado: (2023)

Autophagy in inflammation: the p38α MAPK-ULK1 axis
por: She, Hua, et al.
Publicado: (2018)

Randomised, controlled trial of N-acetylcysteine for treatment of acute exacerbations of chronic obstructive pulmonary disease [ISRCTN21676344]
por: Black, Peter N, et al.
Publicado: (2004)

The Activation of M1 Macrophages is Associated with the JNK-m6A-p38 Axis in Chronic Obstructive Pulmonary Disease
por: Hu, Tingting, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_v64birsumtme5r9bj8qbb11hkf