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HIF-1α/JMJD1A signaling regulates inflammation and oxidative stress following hyperglycemia and hypoxia-induced vascular cell injury

BACKGROUND: Endothelial cell (EC) injury accelerates the progression of diabetic macrovascular complications. Hypoxia is an important cause of EC injury. Hypoxia-inducible factor-1 alpha (HIF-1α) is an important hypoxia regulatory protein. Our previous studies showed that high-glucose and hypoxic co...

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Detalles Bibliográficos
Autores principales: Zhao, Min, Wang, Shaoting, Zuo, Anna, Zhang, Jiaxing, Wen, Weiheng, Jiang, Weiqiang, Chen, Hong, Liang, Donghui, Sun, Jia, Wang, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414688/
https://www.ncbi.nlm.nih.gov/pubmed/34479471
http://dx.doi.org/10.1186/s11658-021-00283-8