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Prostaglandin E(2) Dilates Intracerebral Arterioles When Applied to Capillaries: Implications for Small Vessel Diseases

Prostaglandin E(2) (PGE(2)) has been widely proposed to mediate neurovascular coupling by dilating brain parenchymal arterioles through activation of prostanoid EP4 receptors. However, our previous report that direct application of PGE(2) induces an EP1-mediated constriction strongly argues against...

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Detalles Bibliográficos
Autores principales: Rosehart, Amanda C., Longden, Thomas A., Weir, Nick, Fontaine, Jackson T., Joutel, Anne, Dabertrand, Fabrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414797/
https://www.ncbi.nlm.nih.gov/pubmed/34483880
http://dx.doi.org/10.3389/fnagi.2021.695965