Stability investigations of cytochrome P450 (CYP) enzymes immediately after death in a pig model support the applicability of postmortem hepatic CYP quantification

Quantification of drug‐metabolizing cytochrome P450 (CYP) isoforms using LC–MS/MS has been proposed as a potential way of estimating antemortem CYP levels using postmortem tissue, but the postmortem stability of CYP proteins is incompletely investigated. If one can use data obtained from the analysi...

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Detalles Bibliográficos
Autores principales: Pedersen, Kata W., Hansen, Jakob, Hasselstrøm, Jørgen B., Jornil, Jakob R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415216/
https://www.ncbi.nlm.nih.gov/pubmed/34478246
http://dx.doi.org/10.1002/prp2.860

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415216/
https://www.ncbi.nlm.nih.gov/pubmed/34478246
http://dx.doi.org/10.1002/prp2.860

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