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Monoacylglycerol Lipase Inhibitor MJN110 Reduces Neuronal Hyperexcitability, Restores Dendritic Arborization Complexity, and Regulates Reward-Related Behavior in Presence of HIV-1 Tat
While current therapeutic strategies for people living with human immunodeficiency virus type 1 (HIV-1) suppress virus replication peripherally, viral proteins such as transactivator of transcription (Tat) enter the central nervous system early upon infection and contribute to chronic inflammatory c...
Autores principales: | League, Alexis F., Gorman, Benjamin L., Hermes, Douglas J., Johnson, Clare T., Jacobs, Ian R., Yadav-Samudrala, Barkha J., Poklis, Justin L., Niphakis, Micah J., Cravatt, Benjamin F., Lichtman, Aron H., Ignatowska-Jankowska, Bogna M., Fitting, Sylvia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415271/ https://www.ncbi.nlm.nih.gov/pubmed/34484091 http://dx.doi.org/10.3389/fneur.2021.651272 |
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