Implications of inhibition of Rev1 interaction with Y family DNA polymerases for cisplatin chemotherapy

Chemotherapy with cisplatin becomes limiting due to toxicity and secondary malignancies. In principle, therapeutics could be improved by targeting translesion synthesis (TLS) polymerases (Pols) that promote replication through intrastrand cross-links, the major cisplatin-induced DNA adduct. However,...

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Detalles Bibliográficos
Autores principales: Yoon, Jung-Hoon, Johnson, Robert E., Prakash, Louise, Prakash, Satya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415319/
https://www.ncbi.nlm.nih.gov/pubmed/34385260
http://dx.doi.org/10.1101/gad.348662.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415319/
https://www.ncbi.nlm.nih.gov/pubmed/34385260
http://dx.doi.org/10.1101/gad.348662.121

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