Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion

Multiple G protein-coupled receptors (GPCRs) are expressed in pancreatic islet cells, but the majority have unknown functions. We observed specific GPCRs localized to primary cilia, a prominent signaling organelle, in pancreatic α and β cells. Loss of cilia disrupts β-cell endocrine function, but th...

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Detalles Bibliográficos
Autores principales: Wu, Chien-Ting, Hilgendorf, Keren I., Bevacqua, Romina J., Hang, Yan, Demeter, Janos, Kim, Seung K., Jackson, Peter K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415323/
https://www.ncbi.nlm.nih.gov/pubmed/34385262
http://dx.doi.org/10.1101/gad.348261.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415323/
https://www.ncbi.nlm.nih.gov/pubmed/34385262
http://dx.doi.org/10.1101/gad.348261.121

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