Mutability of mononucleotide repeats, not oxidative stress, explains the discrepancy between laboratory-accumulated mutations and the natural allele-frequency spectrum in C. elegans

Important clues about natural selection can be gleaned from discrepancies between the properties of segregating genetic variants and of mutations accumulated experimentally under minimal selection, provided the mutational process is the same in the laboratory as in nature. The base-substitution spec...

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Detalles Bibliográficos
Autores principales: Rajaei, Moein, Saxena, Ayush Shekhar, Johnson, Lindsay M., Snyder, Michael C., Crombie, Timothy A., Tanny, Robyn E., Andersen, Erik C., Joyner-Matos, Joanna, Baer, Charles F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415377/
https://www.ncbi.nlm.nih.gov/pubmed/34404692
http://dx.doi.org/10.1101/gr.275372.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415377/
https://www.ncbi.nlm.nih.gov/pubmed/34404692
http://dx.doi.org/10.1101/gr.275372.121

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