Co-Stimulatory Bispecific Antibodies Induce Enhanced T Cell Activation and Tumor Cell Killing in Breast Cancer Models

Although T cell-recruiting CD3-binding bispecific antibodies (BiMAb) have been proven to be clinically effective for hematologic malignancies, the success of BiMAb targeting solid tumor-associated antigens (TAA) in carcinomas so far remains poor. We reasoned that provision of co-stimulatory BiMAb in...

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Detalles Bibliográficos
Autores principales: Warwas, Karsten M., Meyer, Marten, Gonçalves, Márcia, Moldenhauer, Gerhard, Bulbuc, Nadja, Knabe, Susanne, Luckner-Minden, Claudia, Ziegelmeier, Claudia, Heussel, Claus Peter, Zörnig, Inka, Jäger, Dirk, Momburg, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415424/
https://www.ncbi.nlm.nih.gov/pubmed/34484225
http://dx.doi.org/10.3389/fimmu.2021.719116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415424/
https://www.ncbi.nlm.nih.gov/pubmed/34484225
http://dx.doi.org/10.3389/fimmu.2021.719116

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