Cargando…

Pharmacokinetics and Pharmacodynamics of a Novel Virulent Klebsiella Phage Kp_Pokalde_002 in a Mouse Model

Phage therapy is one of the most promising alternatives to antibiotics as we face global antibiotic resistance crisis. However, the pharmacokinetics (PK) and pharmacodynamics (PD) of phage therapy are largely unknown. In the present study, we aimed to evaluate the PK/PD of a locally isolated virulen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dhungana, Gunaraj, Nepal, Roshan, Regmi, Madhav, Malla, Rajani
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cellular and Infection Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415502/ https://www.ncbi.nlm.nih.gov/pubmed/34485172 http://dx.doi.org/10.3389/fcimb.2021.684704

Ejemplares similares

Genomic characterization of three bacteriophages targeting multidrug resistant clinical isolates of Escherichia, Klebsiella and Salmonella
por: Nepal, Roshan, et al.
Publicado: (2022)

Complete Genome Sequence of Myophage Ec_Makalu_002, Which Infects Uropathogenic Escherichia coli
por: Dhungana, Gunaraj, et al.
Publicado: (2020)

Capsule-Targeting Depolymerase, Derived from Klebsiella KP36 Phage, as a Tool for the Development of Anti-Virulent Strategy
por: Majkowska-Skrobek, Grażyna, et al.
Publicado: (2016)

Klebsiella Phage KP34 RNA Polymerase and Its Use in RNA Synthesis
por: Lu, Xueling, et al.
Publicado: (2019)

Genome Sequence of KP-Rio/2015, a Novel Klebsiella pneumoniae (Podoviridae) Phage
por: Meira, Guilherme L. S., et al.
Publicado: (2016)

Characterization of Hypervirulent Klebsiella pneumoniae (Hv-Kp): Correlation of Virulence with Antimicrobial Susceptibility
por: Vandhana, V., et al.
Publicado: (2022)

Advantages and limitations of microtiter biofilm assays in the model of antibiofilm activity of Klebsiella phage KP34 and its depolymerase
por: Latka, Agnieszka, et al.
Publicado: (2020)

Characterization of Klebsiella pneumoniae bacteriophages, KP1 and KP12, with deep learning-based structure prediction
por: Kim, Youngju, et al.
Publicado: (2023)

Resistance of Klebsiella pneumoniae to Phage hvKpP3 Due to High-Molecular Weight Lipopolysaccharide Synthesis Failure
por: Geng, Huaixin, et al.
Publicado: (2023)

Isolation and Characterization of Novel Phages Targeting Pathogenic Klebsiella pneumoniae
por: Li, Na, et al.
Publicado: (2021)

Impact of Two Antibiotic Therapies on Clinical Outcome and Gut Microbiota Profile in Liver Transplant Paediatric Candidates Colonized by Carbapenem-Resistant Klebsiella pneumoniae CR-KP
por: Cardile, Sabrina, et al.
Publicado: (2021)

Draft Genome Sequence of Klebsiella pneumoniae Strain KP-1
por: Lee, Kai Wei Kelvin, et al.
Publicado: (2013)

Clinical Challenges with Hypervirulent Klebsiella Pneumoniae (hvKP) in China
por: Chen, Yanzhu, et al.
Publicado: (2021)

Recombinase-Aided Amplification Assay for Rapid Detection of Hypervirulent Klebsiella pneumoniae (hvKp) and Characterization of the hvKp Pathotype
por: Yan, Chao, et al.
Publicado: (2023)

Editorial: Klebsiella pneumoniae: Antimicrobial resistance, virulence and therapeutic strategies
por: Dong, Ning, et al.
Publicado: (2022)

Intestinal Carriage of Extended-Spectrum β-Lactamase- (ESBL-) Possessing Escherichia coli and Klebsiella Species among Nepalese Health Science and Non-Health Science Students
por: Sapkota, Bhawana, et al.
Publicado: (2021)

Comparative genomic analysis of Klebsiella pneumonia (LCT-KP214) and a mutant strain (LCT-KP289) obtained after spaceflight
por: Guo, Yinghua, et al.
Publicado: (2014)

Early Response of Antimicrobial Resistance and Virulence Genes Expression in Classical, Hypervirulent, and Hybrid hvKp-MDR Klebsiella pneumoniae on Antimicrobial Stress
por: Fursova, Anastasiia D., et al.
Publicado: (2021)

Genetic and Functional Characterization of a Conjugative KpVP-2-Type Virulence Plasmid From a Clinical Klebsiella pneumoniae Strain
por: Yang, Xuemei, et al.
Publicado: (2022)

Acquisition of the Conjugative Virulence Plasmid From a CG23 Hypervirulent Klebsiella pneumoniae Strain Enhances Bacterial Virulence
por: Tian, Dongxing, et al.
Publicado: (2021)

A Novel Polysaccharide Depolymerase Encoded by the Phage SH-KP152226 Confers Specific Activity Against Multidrug-Resistant Klebsiella pneumoniae via Biofilm Degradation
por: Wu, Yunqiang, et al.
Publicado: (2019)

Combination Therapy of Phage vB_KpnM_P-KP2 and Gentamicin Combats Acute Pneumonia Caused by K47 Serotype Klebsiella pneumoniae
por: Wang, Zijing, et al.
Publicado: (2021)

Novel Virulence Factors Deciphering Klebsiella pneumoniae KpC4 Infect Maize as a Crossing-Kingdom Pathogen: An Emerging Environmental Threat
por: Huang, Min, et al.
Publicado: (2022)

Emergence of colistin-resistant hypervirulent Klebsiella pneumoniae (CoR-HvKp) in China
por: Liu, Xiaoyu, et al.
Publicado: (2022)

Klebsiella phage KP34gp57 capsular depolymerase structure and function: from a serendipitous finding to the design of active mini-enzymes against K. pneumoniae
por: Maciejewska, Barbara, et al.
Publicado: (2023)

Antibiotic Resistance and Virulence Profiles of Klebsiella pneumoniae Strains Isolated From Different Clinical Sources
por: Ballén, Victoria, et al.
Publicado: (2021)

Covert dissemination of pLVPK-like virulence plasmid in ST29-K54 Klebsiella pneumoniae: emergence of low virulence phenotype strains
por: Qiu, Jiehui, et al.
Publicado: (2023)

Isolation and Characterization of Klebsiella Phages for Phage Therapy
por: Townsend, Eleanor M., et al.
Publicado: (2021)

Isolation and characterisation of KP34—a novel φKMV-like bacteriophage for Klebsiella pneumoniae
por: Drulis-Kawa, Zuzanna, et al.
Publicado: (2011)

Isolation and Characterization of a Novel Klebsiella pneumoniae N4-like Bacteriophage KP8
por: Morozova, Vera, et al.
Publicado: (2019)

Proteus mirabilis and Klebsiella pneumoniae as pathogens capable of causing co-infections and exhibiting similarities in their virulence factors
por: Palusiak, Agata
Publicado: (2022)

Pyroptosis, apoptosis, and autophagy are involved in infection induced by two clinical Klebsiella pneumoniae isolates with different virulence
por: Wang, Xueting, et al.
Publicado: (2023)

Isolation and Characterization of vB_kpnM_17-11, a Novel Phage Efficient Against Carbapenem-Resistant Klebsiella pneumoniae
por: Bai, Jiawei, et al.
Publicado: (2022)

Hybrid Plasmids Encoding Antimicrobial Resistance and Virulence Traits Among Hypervirulent Klebsiella pneumoniae ST2096 in India
por: Shankar, Chaitra, et al.
Publicado: (2022)

Comparative analysis of the complete genome of KPC-2-producing Klebsiella pneumoniae Kp13 reveals remarkable genome plasticity and a wide repertoire of virulence and resistance mechanisms
por: Ramos, Pablo Ivan Pereira, et al.
Publicado: (2014)

Optimization of tannase production by a novel Klebsiella pneumoniae KP715242 using central composite design()
por: Kumar, Mukesh, et al.
Publicado: (2015)

Complete Nucleotide Sequence of Klebsiella pneumoniae Bacteriophage vB_KpnM_KpV477
por: Komisarova, Ekaterina V., et al.
Publicado: (2017)

The Acquisition of Colistin Resistance Is Associated to the Amplification of a Large Chromosomal Region in Klebsiella pneumoniae kp52145
por: Sánchez, María Blanca, et al.
Publicado: (2021)

Characterization of four virulent Klebsiella pneumoniae bacteriophages, and evaluation of their potential use in complex phage preparation
por: Zurabov, Fedor, et al.
Publicado: (2021)

Phage Selective Pressure Reduces Virulence of Hypervirulent Klebsiella pneumoniae Through Mutation of the wzc Gene
por: Song, Lingjie, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_5fsn78e00585e02140cth40jfc