Human Surfactant Protein SP-A1 and SP-A2 Variants Differentially Affect the Alveolar Microenvironment, Surfactant Structure, Regulation and Function of the Alveolar Macrophage, and Animal and Human Survival Under Various Conditions

The human innate host defense molecules, SP-A1 and SP-A2 variants, differentially affect survival after infection in mice and in lung transplant patients. SP-A interacts with the sentinel innate immune cell in the alveolus, the alveolar macrophage (AM), and modulates its function and regulation. SP-...

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Detalles Bibliográficos
Autores principales: Floros, Joanna, Thorenoor, Nithyananda, Tsotakos, Nikolaos, Phelps, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415824/
https://www.ncbi.nlm.nih.gov/pubmed/34484180
http://dx.doi.org/10.3389/fimmu.2021.681639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415824/
https://www.ncbi.nlm.nih.gov/pubmed/34484180
http://dx.doi.org/10.3389/fimmu.2021.681639

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