Linker histone H1.8 inhibits chromatin binding of condensins and DNA topoisomerase II to tune chromosome length and individualization

DNA loop extrusion by condensins and decatenation by DNA topoisomerase II (topo II) are thought to drive mitotic chromosome compaction and individualization. Here, we reveal that the linker histone H1.8 antagonizes condensins and topo II to shape mitotic chromosome organization. In vitro chromatin r...

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Detalles Bibliográficos
Autores principales: Choppakatla, Pavan, Dekker, Bastiaan, Cutts, Erin E, Vannini, Alessandro, Dekker, Job, Funabiki, Hironori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416026/
https://www.ncbi.nlm.nih.gov/pubmed/34406118
http://dx.doi.org/10.7554/eLife.68918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416026/
https://www.ncbi.nlm.nih.gov/pubmed/34406118
http://dx.doi.org/10.7554/eLife.68918

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