Targeting the Microtubule-Network Rescues CTL Killing Efficiency in Dense 3D Matrices

Efficacy of cytotoxic T lymphocyte (CTL)-based immunotherapy is still unsatisfactory against solid tumors, which are frequently characterized by condensed extracellular matrix. Here, using a unique 3D killing assay, we identify that the killing efficiency of primary human CTLs is substantially impai...

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Detalles Bibliográficos
Autores principales: Zhao, Renping, Zhou, Xiangda, Khan, Essak S., Alansary, Dalia, Friedmann, Kim S., Yang, Wenjuan, Schwarz, Eva C., del Campo, Aránzazu, Hoth, Markus, Qu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416057/
https://www.ncbi.nlm.nih.gov/pubmed/34484240
http://dx.doi.org/10.3389/fimmu.2021.729820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416057/
https://www.ncbi.nlm.nih.gov/pubmed/34484240
http://dx.doi.org/10.3389/fimmu.2021.729820

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