A Modern Genotoxicity Testing Paradigm: Integration of the High-Throughput CometChip® and the TGx-DDI Transcriptomic Biomarker in Human HepaRG™ Cell Cultures

Higher-throughput, mode-of-action-based assays provide a valuable approach to expedite chemical evaluation for human health risk assessment. In this study, we combined the high-throughput alkaline DNA damage-sensing CometChip(®) assay with the TGx-DDI transcriptomic biomarker (DDI = DNA damage-induc...

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Detalles Bibliográficos
Autores principales: Buick, Julie K., Williams, Andrew, Meier, Matthew J., Swartz, Carol D., Recio, Leslie, Gagné, Rémi, Ferguson, Stephen S., Engelward, Bevin P., Yauk, Carole L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Public Health
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416458/
https://www.ncbi.nlm.nih.gov/pubmed/34485225
http://dx.doi.org/10.3389/fpubh.2021.694834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416458/
https://www.ncbi.nlm.nih.gov/pubmed/34485225
http://dx.doi.org/10.3389/fpubh.2021.694834

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