Cargando…

Arginine:Glycine Amidinotransferase Is Essential for Creatine Supply in Mice During Chronic Hypoxia

Objective: Chronic hypoxia induces pulmonary and cardiovascular pathologies, including pulmonary hypertension (PH). L-arginine:glycine amidinotransferase (AGAT) is essential for homoarginine (hArg) and guanidinoacetate synthesis, the latter being converted to creatine by guanidinoacetate methyltrans...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hannemann, Juliane, Cordts, Kathrin, Seniuk, Anika, Choe, Chi-un, Schmidt-Hutten, Lena, Duque Escobar, Jorge, Weinberger, Florian, Böger, Rainer, Schwedhelm, Edzard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416470/ https://www.ncbi.nlm.nih.gov/pubmed/34483959 http://dx.doi.org/10.3389/fphys.2021.703069

Ejemplares similares

Analysis of L-arginine:glycine amidinotransferase-, creatine- and homoarginine-dependent gene regulation in the murine heart
por: Jensen, Märit, et al.
Publicado: (2020)

Homoarginine- and Creatine-Dependent Gene Regulation in Murine Brains with l-Arginine:Glycine Amidinotransferase Deficiency
por: Jensen, Märit, et al.
Publicado: (2020)

Expression of cardiovascular-related microRNAs is altered in L-arginine:glycine amidinotransferase deficient mice
por: Jensen, Märit, et al.
Publicado: (2022)

Impaired cardiac contractile function in arginine:glycine amidinotransferase knockout mice devoid of creatine is rescued by homoarginine but not creatine
por: Faller, Kiterie M E, et al.
Publicado: (2018)

Determination of equilibria constants of arginine:glycine amidinotransferase (AGAT)-catalyzed reactions using concentrations of circulating amino acids
por: Tsikas, Dimitrios
Publicado: (2022)

Diurnal Variation of L-Arginine and the Cardiovascular Risk Markers Asymmetric and Symmetric Dimethylarginine and Homoarginine in Rotating Night Shift Workers and Controls
por: Hannemann, Juliane, et al.
Publicado: (2023)

Fifteen-year follow-up of Italian families affected by arginine glycine amidinotransferase deficiency
por: Battini, Roberta, et al.
Publicado: (2017)

Biomarkers of the L-Arginine/Dimethylarginine/Nitric Oxide Pathway in People with Chronic Airflow Obstruction and Obstructive Sleep Apnoea
por: Hannemann, Juliane, et al.
Publicado: (2023)

Arginine Derivatives in Cerebrovascular Diseases: Mechanisms and Clinical Implications
por: Grosse, Gerrit M., et al.
Publicado: (2020)

Creatine, guanidinoacetate and homoarginine in statin-induced myopathy
por: Neu, Axel, et al.
Publicado: (2020)

Genetic diversity and natural selection footprints of the glycine amidinotransferase gene in various human populations
por: Khan, Asifullah, et al.
Publicado: (2016)

Dual role of the L-arginine–ADMA–NO pathway in systemic hypoxic vasodilation and pulmonary hypoxic vasoconstriction
por: Böger, Rainer, et al.
Publicado: (2020)

Arginine derivatives in atrial fibrillation progression phenotypes
por: Büttner, Petra, et al.
Publicado: (2020)

Correction to: Arginine derivatives in atrial fibrillation progression phenotypes
por: Büttner, Petra, et al.
Publicado: (2021)

Association of Lower Plasma Homoarginine Concentrations with Greater Risk of All-Cause Mortality in the Community: The Framingham Offspring Study
por: Schwedhelm, Edzard, et al.
Publicado: (2020)

Characterization of Aphanizomenon ovalisporum amidinotransferase involved in cylindrospermopsin synthesis
por: Barón-Sola, Ángel, et al.
Publicado: (2013)

Characterization of AmtA, an amidinotransferase involved in the biosynthesis of phaseolotoxins
por: Li, Mi, et al.
Publicado: (2016)

Increased creatine demand during pregnancy in Arginine: Glycine Amidino-Transferase deficiency: a case report
por: Alessandrì, Maria Grazia, et al.
Publicado: (2020)

Asymmetric Dimethylarginine at Sea Level Is a Predictive Marker of Hypoxic Pulmonary Arterial Hypertension at High Altitude
por: Siques, Patricia, et al.
Publicado: (2019)

Elevated serum SDMA and ADMA at hospital admission predict in-hospital mortality of COVID-19 patients
por: Hannemann, Juliane, et al.
Publicado: (2021)

Effect of ranolazine on plasma arginine derivatives and urinary isoprostane 8-iso-PGF(2α) in patients with myocardial infarction in the randomized RIMINI-Trial
por: Schwemer, Tjark F., et al.
Publicado: (2019)

Population kinetics of homoarginine and optimized supplementation for cardiovascular risk reduction
por: Kleist, Christine J., et al.
Publicado: (2022)

Developmental dynamics of homoarginine, ADMA and SDMA plasma levels from birth to adolescence
por: Baach, Florence, et al.
Publicado: (2023)

Low Homoarginine Levels in the Prognosis of Patients With Acute Chest Pain
por: Atzler, Dorothee, et al.
Publicado: (2016)

Associations of circulating dimethylarginines with the metabolic syndrome in the Framingham Offspring study
por: Yola, Ibrahim Musa, et al.
Publicado: (2021)

Association of Asymmetric Dimethylarginine and Diastolic Dysfunction in Patients with Hypertrophic Cardiomyopathy
por: Cordts, Kathrin, et al.
Publicado: (2019)

L-Arginine and SDMA Serum Concentrations Are Associated with Subclinical Atherosclerosis in the Study of Health in Pomerania (SHIP)
por: Bahls, Martin, et al.
Publicado: (2015)

Pre-Analytical and Clinical Validation of a Dried Blood Spot Assay for Asymmetric Dimethylarginine and L-Arginine
por: Hannemann, Juliane, et al.
Publicado: (2020)

Homoarginine and creatine deficiency do not exacerbate murine ischaemic heart failure
por: McAndrew, Debra J., et al.
Publicado: (2022)

Association of Genes of the NO Pathway with Altitude Disease and Hypoxic Pulmonary Hypertension
por: Hannemann, Juliane, et al.
Publicado: (2021)

Systemic Effects of Homoarginine Supplementation on Arginine Metabolizing Enzymes in Rats with Heart Failure with Preserved Ejection Fraction
por: Büttner, Petra, et al.
Publicado: (2023)

Deciphering the molecular mechanisms of pulmonary hypoxia and its health sequelae: proceedings of the first international DECIPHER symposium on pulmonary hypoxia, Iquique, Chile, 16–17 October 2019
por: Hannemann, Juliane, et al.
Publicado: (2020)

Dysregulation of the Nitric Oxide/Dimethylarginine Pathway in Hypoxic Pulmonary Vasoconstriction—Molecular Mechanisms and Clinical Significance
por: Hannemann, Juliane, et al.
Publicado: (2022)

Dimethylarginine Dimethylaminohydrolase-1 Transgenic Mice Are Not Protected from Ischemic Stroke
por: Leypoldt, Frank, et al.
Publicado: (2009)

Homoarginine Associates with Carotid Intima-Media Thickness and Atrial Fibrillation and Predicts Adverse Events after Stroke
por: Schwieren, Laura, et al.
Publicado: (2023)

Serum Biomarkers of Endothelial Dysfunction in Fabry Associated Cardiomyopathy
por: Loso, Jefferson, et al.
Publicado: (2018)

Neuropsychological profile and clinical effects of arginine treatment in children with creatine transport deficiency
por: Chilosi, Annamaria, et al.
Publicado: (2012)

Creatine riboside is a cancer cell–derived metabolite associated with arginine auxotrophy
por: Parker, Amelia L., et al.
Publicado: (2022)

A study of endothelial function and circulating asymmetric dimethylarginine levels in people with Type 1 diabetes without macrovascular disease or microalbuminuria
por: Sibal, Latika, et al.
Publicado: (2009)

Plasma Nitrate and Incidence of Cardiovascular Disease and All‐Cause Mortality in the Community: The Framingham Offspring Study
por: Maas, Renke, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_5380b937ram31eem4iahkpjj7s