Inhibition of the MAP2K7-JNK pathway with 5Z-7-oxozeaenol induces apoptosis in T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive pediatric leukemia with a worse prognosis than most frequent B-cell ALL due to a high incidence of treatment failures and relapse. Our previous work showed that loss of the pioneer factor KLF4 in a NOTCH1-induced T-ALL mouse model accelera...

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Detalles Bibliográficos
Autores principales: Chen, Taylor J., Du, Wa, Junco, Jacob J., Bridges, Cory Seth, Shen, Ye, Puppi, Monica, Rabin, Karen R., Lacorazza, H. Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416565/
https://www.ncbi.nlm.nih.gov/pubmed/34504651
http://dx.doi.org/10.18632/oncotarget.28040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416565/
https://www.ncbi.nlm.nih.gov/pubmed/34504651
http://dx.doi.org/10.18632/oncotarget.28040

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