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Effect of Oral Semaglutide on the Pharmacokinetics of Levonorgestrel and Ethinylestradiol in Healthy Postmenopausal Women and Furosemide and Rosuvastatin in Healthy Subjects

BACKGROUND: The first oral glucagon-like peptide-1 receptor agonist (GLP-1RA) comprises semaglutide co-formulated with the absorption enhancer, sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC). Oral semaglutide may alter the pharmacokinetics of co-administered drugs via effects of semaglutide...

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Detalles Bibliográficos
Autores principales: Jordy, Andreas B., Albayaty, Muna, Breitschaft, Astrid, Anderson, Thomas W., Christiansen, Erik, Houshmand-Øregaard, Azadeh, Manigandan, Easwaran, Bækdal, Tine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416862/
https://www.ncbi.nlm.nih.gov/pubmed/33782832
http://dx.doi.org/10.1007/s40262-020-00976-x