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Memory-like Differentiation Enhances NK Cell Responses to Melanoma

PURPOSE: Treatment of advanced melanoma is a clinical challenge. Natural killer (NK) cells are a promising cellular therapy for T cell–refractory cancers, but are frequently deficient or dysfunctional in patients with melanoma. Thus, new strategies are needed to enhance NK-cell antitumor responses....

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Detalles Bibliográficos
Autores principales: Marin, Nancy D., Krasnick, Bradley A., Becker-Hapak, Michelle, Conant, Leah, Goedegebuure, Simon P., Berrien-Elliott, Melissa M., Robbins, Keenan J., Foltz, Jennifer A., Foster, Mark, Wong, Pamela, Cubitt, Celia C., Tran, Jennifer, Wetzel, Christopher B., Jacobs, Miriam, Zhou, Alice Y., Russler-Germain, David, Marsala, Lynne, Schappe, Timothy, Fields, Ryan C., Fehniger, Todd A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416927/
https://www.ncbi.nlm.nih.gov/pubmed/34187852
http://dx.doi.org/10.1158/1078-0432.CCR-21-0851