The Impact of the Triglyceride-Glucose Index on Poor Prognosis in NonDiabetic Patients Undergoing Percutaneous Coronary Intervention

BACKGROUND: The triglyceride-glucose index (TyG index) is a valuable marker for predicting adverse cardiovascular events in diabetic patients. However, for nondiabetic patients, whether the TyG index is independently related to poor prognosis remains unclear. This cohort study assessed the associati...

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Autores principales: Yang, Jie, Tang, Yi-Da, Zheng, Yitian, Li, Chen, Zhou, Qing, Gao, Jun, Meng, Xiangbin, Zhang, Kuo, Wang, Wenyao, Shao, Chunli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417234/
https://www.ncbi.nlm.nih.gov/pubmed/34489866
http://dx.doi.org/10.3389/fendo.2021.710240
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author Yang, Jie
Tang, Yi-Da
Zheng, Yitian
Li, Chen
Zhou, Qing
Gao, Jun
Meng, Xiangbin
Zhang, Kuo
Wang, Wenyao
Shao, Chunli
author_facet Yang, Jie
Tang, Yi-Da
Zheng, Yitian
Li, Chen
Zhou, Qing
Gao, Jun
Meng, Xiangbin
Zhang, Kuo
Wang, Wenyao
Shao, Chunli
author_sort Yang, Jie
collection PubMed
description BACKGROUND: The triglyceride-glucose index (TyG index) is a valuable marker for predicting adverse cardiovascular events in diabetic patients. However, for nondiabetic patients, whether the TyG index is independently related to poor prognosis remains unclear. This cohort study assessed the association of the TyG index with future cardiovascular risk in nondiabetic subjects who received percutaneous coronary intervention (PCI). METHODS: We consecutively enrolled 5,489 nondiabetic patients who underwent PCI. All experimental subjects were divided into three groups based on their TyG index, which was determined by the equation ln (fasting triglyceride (mg/dl) × fasting blood glucose (mg/dl)/2). The primary endpoint was major adverse cardiovascular and cerebrovascular events (MACCE), including all-cause death, nonfatal myocardial infarction (MI), nonfatal stroke, and target vessel revascularization (TVR). RESULTS: A total of 386 MACCE were documented during a median 29-month follow-up. The Kaplan–Meier survival results indicated that among the three groups, there was no obvious difference in any endpoints. Further Cox regression analyses suggested that the TyG index was not independently related to adverse cardiovascular outcomes for nondiabetic patients who underwent PCI (HR: 0.77, 95% CI 0.56–1.16, P = 0.210 for MACCE). Subgroup analysis suggested that the TyG index was independently relevant to MACCE for patients with low-density lipoprotein cholesterol (LDL-C) lower than 1.8 mmol/L. CONCLUSION: The TyG index is not an effective predictive factor for adverse cardiovascular prognosis in nondiabetic patients who underwent PCI. However, in subjects with LDL-C lower than 1.8mmol/L, it may predict future cardiovascular risk.
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spelling pubmed-84172342021-09-05 The Impact of the Triglyceride-Glucose Index on Poor Prognosis in NonDiabetic Patients Undergoing Percutaneous Coronary Intervention Yang, Jie Tang, Yi-Da Zheng, Yitian Li, Chen Zhou, Qing Gao, Jun Meng, Xiangbin Zhang, Kuo Wang, Wenyao Shao, Chunli Front Endocrinol (Lausanne) Endocrinology BACKGROUND: The triglyceride-glucose index (TyG index) is a valuable marker for predicting adverse cardiovascular events in diabetic patients. However, for nondiabetic patients, whether the TyG index is independently related to poor prognosis remains unclear. This cohort study assessed the association of the TyG index with future cardiovascular risk in nondiabetic subjects who received percutaneous coronary intervention (PCI). METHODS: We consecutively enrolled 5,489 nondiabetic patients who underwent PCI. All experimental subjects were divided into three groups based on their TyG index, which was determined by the equation ln (fasting triglyceride (mg/dl) × fasting blood glucose (mg/dl)/2). The primary endpoint was major adverse cardiovascular and cerebrovascular events (MACCE), including all-cause death, nonfatal myocardial infarction (MI), nonfatal stroke, and target vessel revascularization (TVR). RESULTS: A total of 386 MACCE were documented during a median 29-month follow-up. The Kaplan–Meier survival results indicated that among the three groups, there was no obvious difference in any endpoints. Further Cox regression analyses suggested that the TyG index was not independently related to adverse cardiovascular outcomes for nondiabetic patients who underwent PCI (HR: 0.77, 95% CI 0.56–1.16, P = 0.210 for MACCE). Subgroup analysis suggested that the TyG index was independently relevant to MACCE for patients with low-density lipoprotein cholesterol (LDL-C) lower than 1.8 mmol/L. CONCLUSION: The TyG index is not an effective predictive factor for adverse cardiovascular prognosis in nondiabetic patients who underwent PCI. However, in subjects with LDL-C lower than 1.8mmol/L, it may predict future cardiovascular risk. Frontiers Media S.A. 2021-08-19 /pmc/articles/PMC8417234/ /pubmed/34489866 http://dx.doi.org/10.3389/fendo.2021.710240 Text en Copyright © 2021 Yang, Tang, Zheng, Li, Zhou, Gao, Meng, Zhang, Wang and Shao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Yang, Jie
Tang, Yi-Da
Zheng, Yitian
Li, Chen
Zhou, Qing
Gao, Jun
Meng, Xiangbin
Zhang, Kuo
Wang, Wenyao
Shao, Chunli
The Impact of the Triglyceride-Glucose Index on Poor Prognosis in NonDiabetic Patients Undergoing Percutaneous Coronary Intervention
title The Impact of the Triglyceride-Glucose Index on Poor Prognosis in NonDiabetic Patients Undergoing Percutaneous Coronary Intervention
title_full The Impact of the Triglyceride-Glucose Index on Poor Prognosis in NonDiabetic Patients Undergoing Percutaneous Coronary Intervention
title_fullStr The Impact of the Triglyceride-Glucose Index on Poor Prognosis in NonDiabetic Patients Undergoing Percutaneous Coronary Intervention
title_full_unstemmed The Impact of the Triglyceride-Glucose Index on Poor Prognosis in NonDiabetic Patients Undergoing Percutaneous Coronary Intervention
title_short The Impact of the Triglyceride-Glucose Index on Poor Prognosis in NonDiabetic Patients Undergoing Percutaneous Coronary Intervention
title_sort impact of the triglyceride-glucose index on poor prognosis in nondiabetic patients undergoing percutaneous coronary intervention
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417234/
https://www.ncbi.nlm.nih.gov/pubmed/34489866
http://dx.doi.org/10.3389/fendo.2021.710240
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