Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice

Intervertebral disc degeneration is highly prevalent within the elderly population and is a leading cause of chronic back pain and disability. Due to the link between disc degeneration and senescence, we explored the ability of the Dasatinib and Quercetin drug combination (D + Q) to prevent an age-d...

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Detalles Bibliográficos
Autores principales: Novais, Emanuel J., Tran, Victoria A., Johnston, Shira N., Darris, Kayla R., Roupas, Alex J., Sessions, Garrett A., Shapiro, Irving M., Diekman, Brian O., Risbud, Makarand V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417260/
https://www.ncbi.nlm.nih.gov/pubmed/34480023
http://dx.doi.org/10.1038/s41467-021-25453-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417260/
https://www.ncbi.nlm.nih.gov/pubmed/34480023
http://dx.doi.org/10.1038/s41467-021-25453-2

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